SCHEMBL185682

SCHEMBL185682

COC(=O)c1ccc(Oc2ccc3nc(NC(=O)C(Oc4ccc(F)cc4F)c4ccc(S(=O)(=O)C5CC5)cc4)sc3n2)cc1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 19/20 0.63
BRAF P15056 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL185200 0.93 GCK (0.72) GCK
SCHEMBL184798 0.89 GCK (0.60) GCK
SCHEMBL185597 0.86 GCK (0.66) GCK
SCHEMBL184388 0.85 GCK (0.86) GCK
SCHEMBL3761825 0.84 GCK (0.61) GCK
SCHEMBL19921734 0.83 GCK (0.65) GCK
SCHEMBL185304 0.83 GCK (0.87) GCK
SCHEMBL184874 0.82 GCK (0.57) GCK
SCHEMBL3767927 0.81 GCK (0.58) GCK
SCHEMBL3761770 0.81 GCK (0.70) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2402327-A1 Acetamide compounds as glucokinase activators, their process and medicinal applications Advinus Therapeutics Private Limited (IN) 2012-01-04 EP claimed
EP-2402327-B1 Acetamide compounds as glucokinase activators, their process and medicinal applications IMPETIS BIOSCIENCES LTD (IN) 2018-03-07 EP disclosed
EP-2402327-A1 Acetamide compounds as glucokinase activators, their process and medicinal applications Advinus Therapeutics Private Limited (IN) 2012-01-04 EP disclosed