Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18568596 | 0.90 | GCK (0.31) | GCKCYP2C8CYP2C9HCAR2 | |
| SCHEMBL18568986 | 0.88 | GCK (0.36) | GCK | |
| SCHEMBL18568741 | 0.87 | GCK (0.31) | GCK | |
| SCHEMBL1653299 | 0.86 | GCK (0.36) | GCKMTNR1AMTNR1BNR4A2CYP4F2 | |
| SCHEMBL18569100 | 0.85 | — | — | |
| SCHEMBL18568743 | 0.85 | GCK (0.34) | GCK | |
| SCHEMBL18568913 | 0.83 | — | — | |
| SCHEMBL18569087 | 0.83 | SRC (0.30) | — | |
| SCHEMBL18569106 | 0.82 | HTR2C (0.34) | CYP4F2CYP4A11 | |
| SCHEMBL18569067 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308839-B1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-03-01 | — | — | EP | disclosed |