Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.60 |
| ▸ | METTL3 | Q86U44 | 10/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.59 |
| ▸ | ADK | P55263 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571828 | 0.93 | PRMT5 (0.70) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18571819 | 0.83 | PRMT5 (0.66) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18571827 | 0.82 | PRMT5 (0.74) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18571813 | 0.79 | PRMT5 (0.76) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18571811 | 0.79 | PRMT5 (0.75) | PRMT5METTL3WDR77ADK | |
| SCHEMBL23892655 | 0.78 | PRMT5 (0.47) | PRMT5METTL3WDR77 | |
| SCHEMBL18571825 | 0.78 | PRMT5 (0.74) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18571816 | 0.78 | PRMT5 (0.69) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18572930 | 0.78 | PRMT5 (0.73) | PRMT5METTL3WDR77ADK | |
| SCHEMBL18572956 | 0.78 | PRMT5 (0.76) | PRMT5METTL3WDR77ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |