Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | ADK | P55263 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | AMD1 | P17707 | 2/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572642 | 0.89 | PRMT5 (0.56) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL9915115 | 0.86 | PI4KA (0.55) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL22334075 | 0.85 | PI4KA (0.69) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL22334076 | 0.85 | PI4KA (0.69) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL15397029 | 0.85 | PI4KA (0.69) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL22434784 | 0.85 | PI4KA (0.69) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL18572224 | 0.85 | PRMT5 (0.52) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL15506579 | 0.83 | PI4KA (0.53) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL16882801 | 0.83 | PI4KA (0.53) | PRMT5WDR77RXFP1PI4KAPI4K2B | |
| SCHEMBL18571925 | 0.82 | PRMT5 (0.58) | PRMT5WDR77RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |