Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.55 |
| ▸ | CCR9 | P51686 | 5/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10248530 | 0.73 | CCR9 (0.77) | CCR9CCR2LMNAHTTALDH1A1 | |
| SCHEMBL11181058 | 0.71 | C5AR1 (1.00) | C5AR1CCR9GABRPGABRDGABRA1 | |
| SCHEMBL14319951 | 0.70 | C5AR1 (0.81) | C5AR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11309965 | 0.70 | C5AR1 (0.56) | C5AR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8989941 | 0.69 | C5AR1 (0.53) | C5AR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL368249 | 0.69 | RECQL (0.54) | CCR9CCR2MAPTSMN1; SMN2 | |
| Vercirnon SCHEMBL342225 | 0.67 | CCR9 (1.00) | CCR9CCR2LMNAHTTMAPT | |
| Vercirnon SCHEMBL15766988 | 0.67 | CCR9 (0.98) | CCR9CCR2LMNAHTTMAPT | |
| Vercirnon Sodium SCHEMBL30432616 | 0.67 | CCR9 (0.64) | CCR9CCR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL10252607 | 0.66 | CCR9 (0.61) | CCR9CCR2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748146-B1 | A CRYSTALLINE FORM OF THE SODIUM SALT OF 4-TERT-BUTYL-N-[4-CHLORO-2-(1-OXY-PYRIDINE-4-CARBONYL)-PHENYL]-BENZENE SULFONAMIDE | CHEMOCENTRYX INC (US) | 2017-03-08 | — | — | EP | disclosed |