Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.49 |
| ▸ | KDM5A | P29375 | 2/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18579255 | 0.86 | KDM5B (0.61) | KDM4CCYP11B1CYP11B2KDM4AKDM5B | |
| SCHEMBL24845216 | 0.79 | CYP11B1 (0.58) | KDM4CCYP11B1CYP11B2HPGDSNPC1 | |
| SCHEMBL16033705 | 0.79 | KDM4C (1.00) | KDM4CKDM4AKDM5BKDM5A | |
| SCHEMBL18579809 | 0.77 | KDM5B (0.65) | KDM4CKDM4AKDM5BKDM5ANPC1 | |
| SCHEMBL25583831 | 0.77 | CYP11B1 (0.55) | KDM4CCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL2979521 | 0.77 | CYP11B1 (0.55) | KDM4CCYP11B1CYP11B2HPGDSNPC1 | |
| SCHEMBL24845219 | 0.77 | CYP11B1 (0.55) | KDM4CCYP11B1CYP11B2HPGDSNPC1 | |
| SCHEMBL18579569 | 0.75 | KDM5B (0.62) | KDM4CKDM4AKDM5BKDM5ANPC1 | |
| SCHEMBL21430203 | 0.74 | PHF8 (0.58) | KDM4CCYP11B1CYP11B2KDM4AKDM5B | |
| SCHEMBL15957010 | 0.72 | KDM4C (0.65) | KDM4CCYP11B1CYP11B2KDM4AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963441-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE PHARMACEUTICALS INC (US) | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM3B | KDM4C 13/4885CYP11B1 1296/4885CYP11B2 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.