Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.39 |
| ▸ | KIT | P10721 | 9/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL14856648 | 0.97 | FLT3 (0.38) | FLT3KITCNR2DHODHKDM1A | |
| SCHEMBL185476 | 0.90 | KIT (0.40) | FLT3KITCNR2DHODH | |
| SCHEMBL185393 | 0.89 | CNR2 (0.42) | FLT3KITCNR2RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL14856625 | 0.86 | CNR2 (0.40) | FLT3KITCNR2RAB9AKDM4E | |
| SCHEMBL2807621 | 0.84 | CNR2 (0.40) | FLT3KITCNR2NPC1RAB9A | |
| SCHEMBL2808542 | 0.83 | CNR2 (0.41) | FLT3KITCNR2NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL2813582 | 0.82 | CNR2 (0.39) | CNR2DHODHNPC1RAB9AMPO | |
| SCHEMBL2805079 | 0.82 | CNR2 (0.39) | CNR2DHODHNPC1RAB9AMPO | |
| SCHEMBL2808884 | 0.81 | CNR2 (0.40) | FLT3KITCNR2NPC1RAB9A | |
| SCHEMBL13160090 | 0.81 | MAPK10 (0.41) | FLT3CNR2CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |