Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18609558 | 0.75 | FYN (0.61) | FYNMAPTKMT2AUSP2 | |
| SCHEMBL21644090 | 0.73 | FYN (0.72) | FYNMAPTKMT2AUSP2 | |
| SCHEMBL5408543 | 0.73 | FLT3 (0.49) | FYNMAPTKMT2AUSP2KDM4E | |
| SCHEMBL5408534 | 0.73 | USP2 (0.49) | FYNMAPTKMT2AUSP2KDM4E | |
| SCHEMBL3471979 | 0.70 | TTK (0.61) | FYNMAPTKMT2AUSP2KDM4E | |
| SCHEMBL6923809 | 0.70 | CA12 (0.54) | FYNMAPTKMT2AUSP2KDM4E | |
| SCHEMBL3469850 | 0.69 | CLK4 (0.51) | FYNMAPTKMT2AKDM4EDYRK1A | |
| SCHEMBL3469485 | 0.69 | TTK (0.57) | FYNMAPTKMT2AUSP2KDM4E | |
| SCHEMBL21644020 | 0.68 | FYN (0.91) | FYNDYRK1A | |
| SCHEMBL7682288 | 0.68 | KDR (0.65) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344039-A1 | SMALL MOLECULE INHIBITORS OF DYRK1A AND USES THEREOF | Arizona Board of Regents on behalf of the University of Arizona (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017040993-A1 | SMALL MOLECULE INHIBITORS OF DYRK1A AND USES THEREOF | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-03-09 | — | — | WO | disclosed |