Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.69 |
| ▸ | BRD2 | P25440 | 2/20 | 0.68 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.68 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.68 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.68 |
| ▸ | BRD1 | O95696 | 1/20 | 0.68 |
| ▸ | CCL2 | P13500 | 1/20 | 0.68 |
| ▸ | TAF1 | P21675 | 1/20 | 0.68 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.68 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.68 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.68 |
| ▸ | EP300 | Q09472 | 1/20 | 0.68 |
| ▸ | BPTF | Q12830 | 1/20 | 0.68 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.68 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.68 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.68 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.68 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.68 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.68 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30646996 | 0.95 | BRD4 (0.67) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL20494447 | 0.95 | BRD4 (0.67) | BRD4BRD2BRD3BRDTTRIM24 | |
| Hydrochloric Acid SCHEMBL20494545 | 0.94 | BRD4 (0.66) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18584535 | 0.87 | BRD4 (0.68) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18616953 | 0.83 | BRD4 (0.61) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL20494133 | 0.82 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617291 | 0.82 | BRD4 (0.84) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18584924 | 0.81 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL29092692 | 0.81 | BRD4 (0.84) | BRD4BRD2BRD3BRDTTRIM24 | |
| Gsk620 SCHEMBL18584671 | 0.81 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-10-01 | — | — | US | claimed |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-09-13 | — | — | US | claimed |
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2021-02-23 | — | — | US | disclosed |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2021-02-23 | — | — | US | disclosed |
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-10-01 | — | — | US | disclosed |
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-10-01 | — | — | US | disclosed |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-09-13 | — | — | US | disclosed |
| EP-3344615-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | BRD4 1/4885BRD2 5/4885BRD3 2/4885 |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | BRD4 1/4885BRD2 5/4885BRD3 2/4885 |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | BRD4 1/4885BRD2 5/4885BRD3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.