Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 6/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18550118 | 0.90 | FFAR1 (0.43) | FFAR1ACACBKCNJ1KCNH2JAK2 | |
| SCHEMBL18549879 | 0.86 | KCNJ1 (0.39) | KCNJ1KCNH2NPSR1 | |
| SCHEMBL18550362 | 0.84 | S1PR5 (0.51) | FFAR1PRMT5WDR77 | |
| SCHEMBL18550151 | 0.83 | S1PR5 (0.41) | KCNJ1KCNH2PRMT5WDR77THRB | |
| SCHEMBL18550284 | 0.82 | S1PR5 (0.52) | FFAR1 | |
| SCHEMBL18550451 | 0.82 | S1PR1 (0.43) | FFAR1KCNJ1KCNH2 | |
| SCHEMBL18586926 | 0.81 | S1PR1 (0.39) | KCNJ1KCNH2 | |
| SCHEMBL18586924 | 0.81 | S1PR1 (0.39) | KCNJ1KCNH2 | |
| SCHEMBL18549956 | 0.81 | KCNJ1 (0.41) | KCNJ1KCNH2 | |
| SCHEMBL18550422 | 0.80 | MAOB (0.47) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368107-B | Fused heterocyclic compounds as S1P modulators | 艾伯维公司 | 2021-11-26 | — | — | CN | disclosed |
| EP-3341369-A1 | FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS | AbbVie Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017036978-A1 | FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS | ABBVIE INC. (US) | 2017-03-09 | — | — | WO | disclosed |