Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 19/20 | 1.00 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18554053 | 0.99 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL18593892 | 0.92 | TLR8 (1.00) | TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL18554050 | 0.91 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL18554044 | 0.83 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL18593897 | 0.83 | TLR8 (0.70) | TLR8TLR7 | |
| SCHEMBL6263720 | 0.81 | TLR8 (0.82) | TLR8TLR7 | |
| SCHEMBL18554065 | 0.80 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL18554007 | 0.80 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL16836314 | 0.80 | TLR8 (0.79) | TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL18554031 | 0.79 | TLR8 (1.00) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002251-A1 | HUMAN TLR8-SELECTIVE AGONISTS | UNIVERSITY OF KANSAS (US) | 2022-01-06 | — | — | US | disclosed |
| US-11130736-B2 | Human TLR8-selective agonists | UNIVERSITY OF KANSAS (US) | 2021-09-28 | — | — | US | disclosed |
| WO-2017034986-A1 | HUMAN TLR8-SELECTIVE AGONISTS | UNIVERSITY OF KANSAS (US) | 2017-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130736-B2 | Human TLR8-selective agonists | TLR7, TLR8, TLR9 | TLR8 2/4885TLR7 1/4885 |
| US-20220002251-A1 | HUMAN TLR8-SELECTIVE AGONISTS | TLR7, TLR8, TLR9 | TLR8 2/4885TLR7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.