Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.57 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.56 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.56 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.56 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.56 |
| ▸ | GLI1 | P08151 | 1/20 | 0.55 |
| ▸ | GLI2 | P10070 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | CPA1 | P15085 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14521444 | 0.87 | CYP2D6 (0.61) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL12017299 | 0.87 | POLB (0.68) | GAAEPHX2POLB | |
| SCHEMBL10031627 | 0.87 | POLB (0.68) | GAAEPHX2POLB | |
| SCHEMBL22080072 | 0.87 | POLB (0.68) | GAAEPHX2POLB | |
| SCHEMBL17037444 | 0.85 | EPHX2 (0.59) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL8493639 | 0.80 | EPHX2 (0.71) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL14544605 | 0.80 | SMN1; SMN2 (0.69) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL18324609 | 0.80 | GAA (0.68) | GAAGLI1GLI2POLB | |
| SCHEMBL30941666 | 0.79 | EPHX2 (0.69) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL16552390 | 0.79 | EPHX2 (0.64) | GAAEPHX2PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |