Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.82 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.82 |
| ▸ | SRC | P12931 | 3/20 | 0.74 |
| ▸ | KIT | P10721 | 2/20 | 0.74 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.74 |
| ▸ | GAK | O14976 | 2/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | JAK3 | P52333 | 2/20 | 0.74 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.74 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.74 |
| ▸ | CIT | O14578 | 1/20 | 0.74 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.74 |
| ▸ | STK17B | O94768 | 1/20 | 0.74 |
| ▸ | STK10 | O94804 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15772811 | 0.91 | EGFR (0.84) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL14149040 | 0.91 | EGFR (0.84) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL30115330 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL14427862 | 0.90 | EGFR (0.95) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL33143 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL18595835 | 0.89 | EGFR (0.78) | EGFRERBB2ERBB4SRCGAK | |
| SCHEMBL12936080 | 0.88 | EGFR (0.81) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL18595815 | 0.88 | EGFR (0.70) | EGFRERBB2ERBB4SRCGAK | |
| SCHEMBL15772984 | 0.87 | EGFR (0.85) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL15781145 | 0.87 | EGFR (0.85) | EGFRERBB2ERBB4SRCKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586939-B2 | Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2017-03-07 | — | — | US | disclosed |