Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030 | 1.00 | GCKR (0.60) | GCKRGCK | |
| SCHEMBL18327 | 0.93 | GCK (0.71) | GCKRGCK | |
| SCHEMBL17143 | 0.93 | GCK (0.71) | GCKRGCK | |
| SCHEMBL18729 | 0.93 | GCK (0.71) | GCKRGCK | |
| SCHEMBL18599 | 0.93 | GCK (0.71) | GCKRGCK | |
| SCHEMBL12078575 | 0.93 | GCK (0.71) | GCKRGCK | |
| SCHEMBL12090048 | 0.92 | GCKR (0.61) | GCKRGCK | |
| SCHEMBL12090105 | 0.92 | GCKR (0.61) | GCKRGCK | |
| SCHEMBL12090029 | 0.92 | GCKR (0.61) | GCKRGCK | |
| SCHEMBL19995 | 0.84 | GCKR (0.59) | GCKRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |