Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447385 | 0.93 | GAA (0.44) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17438101 | 0.92 | GAA (0.46) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17438065 | 0.89 | NPC1 (0.45) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL18910590 | 0.88 | GAA (0.41) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17447430 | 0.86 | GAA (0.39) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL18568336 | 0.86 | GAA (0.46) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17438103 | 0.85 | GAA (0.48) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17438050 | 0.85 | MAPT (0.57) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17438052 | 0.85 | MAPT (0.57) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL18596301 | 0.83 | GAA (0.43) | GAAMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586890-B2 | Screening methods for the binding affinity of chemical entities to biological molecules and NEDD4-1 inhibitors identified by the screening methods | NORTHWESTERN UNIVERSITY (US) | 2017-03-07 | — | — | US | disclosed |