Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.52 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345 | 0.90 | LPAR1 (0.53) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL2292498 | 0.85 | LPAR1 (0.67) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4587 | 0.82 | LPAR1 (0.53) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL2796554 | 0.82 | LPAR1 (0.68) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4489 | 0.82 | LPAR1 (0.44) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4037272 | 0.82 | MAPT (0.54) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL2800110 | 0.81 | LPAR1 (0.65) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL5585 | 0.80 | LPAR1 (0.47) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4163 | 0.79 | LPAR1 (0.54) | LPAR1LPAR3MAPTABCC3ABCC4 | |
| SCHEMBL5213 | 0.78 | LPAR1 (0.51) | LPAR1LPAR3MAPTABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |