Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 14/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.63 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.63 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.63 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.63 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761256 | 0.86 | LPAR1 (0.73) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL3633 | 0.86 | LPAR1 (0.64) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL18597789 | 0.85 | ABCC3 (0.51) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL10560 | 0.83 | LPAR1 (0.61) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL2761479 | 0.83 | LPAR1 (0.69) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL7139 | 0.82 | LPAR1 (0.55) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL6316 | 0.82 | LPAR1 (0.66) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL17266903 | 0.82 | LPAR1 (0.55) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL2796554 | 0.82 | LPAR1 (0.68) | LPAR1CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL7457 | 0.82 | LPAR1 (0.60) | LPAR1CYP2C9ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022100625-A1 | NITROGEN-SUBSTITUTED AMINOCARBONATE THIOPHENE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| WO-2022100623-A1 | NITROGEN-SUBSTITUTED HETEROCYCLIC THIOPHENE COMPOUNDS AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| EP-2648726-B1 | POLYCYCLIC LPA1 ANTAGONIST AND USES THEREOF | AMIRA PHARMACEUTICALS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |