Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.43 |
| ▸ | ACE | P12821 | 9/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14900580 | 0.83 | MME (0.62) | MMEACEMMEL1 | |
| SCHEMBL14900581 | 0.75 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL23055193 | 0.75 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL17011366 | 0.75 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL19190446 | 0.75 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL14890894 | 0.72 | MME (0.78) | MMEACEMMEL1 | |
| SCHEMBL18597854 | 0.71 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL14932476 | 0.71 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL14890856 | 0.71 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16930520 | 0.70 | MME (0.55) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |