Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.64 |
| ▸ | ACE | P12821 | 11/20 | 0.64 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.51 |
| ▸ | EMG1 | Q92979 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597895 | 0.86 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL14890645 | 0.86 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL14900578 | 0.83 | MME (0.73) | MMEACEMMEL1 | |
| SCHEMBL18597848 | 0.83 | MME (0.73) | MMEACEMMEL1 | |
| SCHEMBL18597868 | 0.79 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL14890447 | 0.79 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL16008638 | 0.78 | MME (0.83) | MMEACEMMEL1 | |
| SCHEMBL14892167 | 0.78 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL14890711 | 0.78 | MME (0.70) | MMEACEMMEL1 | |
| SCHEMBL18597872 | 0.78 | MME (0.70) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |