Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11326483 | 1.00 | BACE1 (0.57) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL11886481 | 0.90 | BACE1 (0.48) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL15986167 | 0.89 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL11888116 | 0.87 | BACE1 (0.51) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL20341373 | 0.87 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL18011791 | 0.87 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL11028559 | 0.86 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL15986391 | 0.86 | BACE1 (0.53) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2622844 | 0.86 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL11888095 | 0.86 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |