Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680210 | 0.68 | MAPT (1.00) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL29714346 | 0.55 | MEN1 (0.44) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL3971277 | 0.55 | MEN1 (0.44) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL29714341 | 0.55 | MEN1 (0.44) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL22174938 | 0.54 | KMT2A (0.43) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL29990662 | 0.54 | KMT2A (0.43) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL12631830 | 0.54 | AURKA (0.46) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL1356072 | 0.54 | AURKA (0.46) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL19453382 | 0.53 | KDM4E (0.35) | MAPTKDM4ENPSR1MEN1KMT2A | |
| SCHEMBL22184578 | 0.53 | KMT2A (0.42) | MAPTKDM4ENPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138838-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |