Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 18/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.73 |
| ▸ | MTOR | P42345 | 8/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146765 | 0.89 | PIK3CA (0.80) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2147875 | 0.88 | PIK3CA (0.79) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2147453 | 0.85 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2146849 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14716370 | 0.82 | PIK3R1 (0.83) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL16881784 | 0.82 | PIK3CA (0.69) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14716682 | 0.82 | PIK3CA (0.94) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14716371 | 0.82 | PIK3CA (0.82) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14725994 | 0.81 | PIK3CA (0.68) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2147209 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526102-B1 | Inhibitors of PI3 kinase | FUNDACIÓN CENTRO NAC DE INVESTIG ONCOLÓGICAS CARLOS III (ES) | 2017-03-08 | — | — | EP | disclosed |