Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206587 | 0.81 | CHEK1 (0.53) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14207411 | 0.80 | CHEK1 (0.75) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14207423 | 0.78 | PIM1 (0.56) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14207417 | 0.77 | CHEK1 (0.50) | CHEK1 | |
| SCHEMBL18599959 | 0.77 | CHEK1 (0.51) | CHEK1 | |
| SCHEMBL14328719 | 0.77 | CHEK1 (0.70) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14207029 | 0.77 | CHEK1 (0.53) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL11886244 | 0.76 | CHEK1 (0.58) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14206443 | 0.76 | CHEK1 (0.69) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL14217915 | 0.75 | CHEK1 (0.59) | CHEK1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |