Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14328604 | 0.93 | CHEK1 (0.81) | CHEK1 | |
| SCHEMBL14328599 | 0.91 | CHEK1 (0.77) | CHEK1 | |
| SCHEMBL13156153 | 0.90 | CHEK1 (0.85) | CHEK1 | |
| SCHEMBL14206552 | 0.89 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL18600041 | 0.88 | CHEK1 (0.86) | CHEK1 | |
| SCHEMBL14206544 | 0.88 | CHEK1 (0.79) | CHEK1 | |
| SCHEMBL14206447 | 0.88 | CHEK1 (0.73) | CHEK1 | |
| SCHEMBL14328791 | 0.88 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL14328465 | 0.87 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL14206566 | 0.87 | CHEK1 (1.00) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |