Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206481 | 0.89 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL14328817 | 0.87 | CHEK1 (0.76) | CHEK1 | |
| SCHEMBL14328804 | 0.86 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL15071640 | 0.86 | CHEK1 (0.84) | CHEK1 | |
| SCHEMBL14206687 | 0.86 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL14207006 | 0.86 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL14206725 | 0.85 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL14328678 | 0.84 | CHEK1 (0.80) | CHEK1 | |
| SCHEMBL14328814 | 0.84 | CHEK1 (0.68) | CHEK1 | |
| SCHEMBL14328808 | 0.83 | CHEK1 (0.76) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |