Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 20/20 | 0.73 |
| ▸ | CCR5 | P51681 | 1/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.65 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186631 | 0.87 | CCR4 (0.53) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL358176 | 0.84 | CCR4 (0.76) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10234777 | 0.83 | CCR4 (0.90) | CCR4 | |
| SCHEMBL359285 | 0.83 | CCR4 (1.00) | CCR4 | |
| SCHEMBL185878 | 0.83 | CCR4 (0.71) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL186421 | 0.83 | CCR4 (0.88) | CCR4 | |
| SCHEMBL202383 | 0.82 | CCR4 (0.69) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL358630 | 0.82 | CCR4 (1.00) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10234774 | 0.82 | CCR4 (0.81) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL201970 | 0.82 | CCR4 (0.68) | CCR4CCR5FFAR4SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097395-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-09-02 | — | — | WO | disclosed |