Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206461 | 0.83 | CHEK1 (0.56) | CHEK1LMNAGPR6 | |
| SCHEMBL14206414 | 0.78 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL14206610 | 0.78 | CHEK1 (0.54) | CHEK1 | |
| SCHEMBL14206469 | 0.77 | CHEK1 (0.56) | CHEK1LMNA | |
| SCHEMBL18600404 | 0.77 | CHEK1 (0.49) | CHEK1 | |
| SCHEMBL2727017 | 0.76 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL14328826 | 0.76 | CHEK1 (0.57) | CHEK1LMNA | |
| SCHEMBL2727353 | 0.76 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL14207186 | 0.75 | CHEK1 (0.51) | CHEK1 | |
| SCHEMBL14206614 | 0.75 | CHEK1 (0.55) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |