Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPC1L1 | Q9UHC9 | 5/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL319273 | 0.88 | NPC1L1 (0.51) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318225 | 0.85 | NPC1L1 (0.59) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10248363 | 0.84 | NPC1L1 (0.58) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL320092 | 0.83 | NPC1L1 (0.57) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318110 | 0.82 | NPC1L1 (0.55) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5563023 | 0.82 | NPC1L1 (0.64) | NPC1L1DDR1 | |
| SCHEMBL9998932 | 0.81 | NPC1L1 (0.52) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318941 | 0.81 | NPC1L1 (0.52) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318940 | 0.81 | NPC1L1 (0.52) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9999126 | 0.80 | NPC1L1 (0.52) | MEN1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |