Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19062113 | 0.82 | FYN (0.34) | FYNCHEK2CYP2A6 | |
| SCHEMBL22930871 | 0.79 | ACVR2A (0.31) | ACVR2ATGFBR1 | |
| SCHEMBL18602127 | 0.77 | — | — | |
| SCHEMBL20879745 | 0.73 | — | — | |
| SCHEMBL29540476 | 0.73 | PRKCI (0.44) | — | |
| SCHEMBL100026 | 0.73 | PRKCI (0.44) | — | |
| SCHEMBL14517858 | 0.72 | CCNE1 (0.34) | FYNCYP2A6 | |
| SCHEMBL15072224 | 0.70 | CYP2A6 (0.32) | CYP2A6 | |
| SCHEMBL22930989 | 0.68 | — | — | |
| SCHEMBL22930940 | 0.64 | MAP4K4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |