SCHEMBL18602154

SCHEMBL18602154

N#CCC(CC#N)Cc1ncc(-c2ncnc3c2CCN3)s1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.48
JAK1 P23458 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13774796 0.81 JAK2 (0.48) JAK2JAK1
SCHEMBL18599201 0.78 JAK2 (0.56) JAK2JAK1
SCHEMBL21974618 0.76 JAK2 (0.43) JAK2JAK1
SCHEMBL13678287 0.73 JAK2 (0.40) JAK2JAK1
SCHEMBL19062726 0.71 JAK2 (0.39) JAK2JAK1
SCHEMBL13678279 0.67 JAK2 (0.70) JAK2JAK1
SCHEMBL19790052 0.67 JAK2 (0.70) JAK2JAK1
SCHEMBL13078860 0.65 JAK2 (1.00) JAK2JAK1
SCHEMBL12147545 0.65 JAK2 (1.00) JAK2JAK1
SCHEMBL13360713 0.65 JAK2 (1.00) JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2343299-B9 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors INCYTE HOLDINGS CORP (US) 2017-03-08 EP disclosed