Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 1.00 |
| ▸ | ACACA | Q13085 | 1/20 | 1.00 |
| ▸ | ACLY | P53396 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bempedoic Acid SCHEMBL185768 | 1.00 | ACACB (1.00) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL23348922 | 1.00 | ACACB (1.00) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL186486 | 0.98 | ACACB (0.96) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL205270 | 0.98 | ACACB (0.96) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL25936778 | 0.94 | ACACB (0.89) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL12094483 | 0.94 | ACACB (0.88) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL3748635 | 0.94 | ACACB (0.88) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL2737120 | 0.93 | ACACB (0.86) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL186401 | 0.93 | ACACB (0.86) | ACACBACACAACLYFFAR1FFAR4 | |
| SCHEMBL12092725 | 0.93 | ACACB (0.86) | ACACBACACAACLYFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597223-B1 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS INC (US) | 2017-02-22 | — | — | EP | claimed |
| EP-1597223-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2005-11-23 | — | — | EP | claimed |
| WO-2004067489-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2004-08-12 | — | — | WO | claimed |
| EP-2404890-A1 | Hydroxyl compounds and compositions for cholesterol management and related uses | Esperion Therapeutics Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-2402300-A1 | Hydroxyl compounds and compositions for cholesterol management and related uses | Esperion Therapeutics Inc. (US) | 2012-01-04 | — | — | EP | disclosed |