Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64979 | 0.90 | SMN1; SMN2 (0.41) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL64314 | 0.86 | FGFR1 (0.49) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL63375 | 0.86 | FGFR1 (0.41) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL62632 | 0.83 | FGFR1 (0.46) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL63458 | 0.81 | FGFR2 (0.40) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL1862447 | 0.81 | FGFR1 (0.38) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL64369 | 0.79 | FGFR1 (0.44) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL63950 | 0.73 | FGFR1 (0.48) | FGFR1FGFR3MAPTSMN1; SMN2KDR | |
| SCHEMBL64105 | 0.72 | KMT2A (0.41) | FGFR1FGFR2LMNAMAPTPOLB | |
| SCHEMBL63028 | 0.72 | FGFR1 (0.55) | FGFR1NTRK1RETPDGFRBMARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | claimed |