Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.73 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16034424 | 0.85 | KDM4C (1.00) | KDM4CKDM2B | |
| SCHEMBL16033742 | 0.84 | KDM4C (0.71) | KDM4CTGFBR1TGFBR2MAPK13MAPK12 | |
| SCHEMBL18612762 | 0.82 | KDM4C (0.69) | KDM4CKDM2B | |
| SCHEMBL16034172 | 0.79 | KDM4C (1.00) | KDM4CKDM2B | |
| SCHEMBL16033407 | 0.78 | KDM4C (0.70) | KDM4CTGFBR1TGFBR2MAPK14KDM2B | |
| SCHEMBL19628765 | 0.74 | KDM4C (0.74) | KDM4CTGFBR1KDM2B | |
| SCHEMBL19101732 | 0.73 | KDM4C (0.72) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18612761 | 0.73 | KDM4C (0.67) | KDM4CKDM2B | |
| SCHEMBL18612884 | 0.73 | KDM4C (0.70) | KDM4CKDM2B | |
| SCHEMBL16034731 | 0.72 | KDM4C (1.00) | KDM4CKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963441-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE PHARMACEUTICALS INC (US) | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM3B | KDM4C 13/4885TGFBR1 2464/4885TGFBR2 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.