Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18629599 | 1.00 | ABCB1 (0.43) | ABCB1MAPTNPC1MITFHTT | |
| SCHEMBL24026905 | 1.00 | ABCB1 (0.43) | ABCB1MAPTNPC1MITFHTT | |
| SCHEMBL25782621 | 1.00 | ABCB1 (0.43) | ABCB1MAPTNPC1MITFHTT | |
| SCHEMBL18629597 | 1.00 | ABCB1 (0.43) | ABCB1MAPTNPC1MITFHTT | |
| SCHEMBL25784631 | 0.82 | ABCB1 (0.41) | ABCB1MAPTKMT2AGAAHPGD | |
| SCHEMBL8630325 | 0.82 | ABCB1 (0.41) | ABCB1MAPTKMT2AGAAHPGD | |
| SCHEMBL8630324 | 0.82 | ABCB1 (0.41) | ABCB1MAPTKMT2AGAAHPGD | |
| SCHEMBL23008043 | 0.82 | ABCB1 (0.41) | ABCB1MAPTKMT2AGAAHPGD | |
| SCHEMBL18629603 | 0.79 | ABCB1 (0.40) | ABCB1GAAHPGDTSHRHSD17B10 | |
| SCHEMBL18629601 | 0.75 | ABCB1 (0.35) | ABCB1KMT2APTGS2MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347348-B1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE INC (US) | 2021-11-17 | — | — | EP | claimed |
| US-20190322635-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-10-24 | — | — | US | claimed |
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2019-09-03 | — | — | US | claimed |
| US-20190002424-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-01-03 | — | — | US | claimed |
| EP-3347348-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 Science, Inc. (US) | 2018-07-18 | — | — | EP | claimed |
| WO-2017044957-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2017-03-16 | — | — | WO | claimed |
| JP-2023145671-A | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | ピー２・サイエンス・インコーポレイテッド | 2023-10-11 | — | — | JP | disclosed |
| US-11434216-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2022-09-06 | — | — | US | disclosed |
| US-11434216-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2022-09-06 | — | — | US | disclosed |
| JP-2022036968-A | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVE THEREOF | ピー２・サイエンス・インコーポレイテッド | 2022-03-08 | — | — | JP | disclosed |
| JP-2022036968-A | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVE THEREOF | ピー２・サイエンス・インコーポレイテッド | 2022-03-08 | — | — | JP | disclosed |
| EP-3347348-B1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE INC (US) | 2021-11-17 | — | — | EP | disclosed |
| US-20210230132-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2021-07-29 | — | — | US | disclosed |
| US-11008299-B2 | Preparation of 3-hydroxy-3,6- dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| US-20190322635-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-10-24 | — | — | US | disclosed |
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-20190002424-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| EP-3347348-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 Science, Inc. (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017044957-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
| US-20190002424-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
| US-11008299-B2 | Preparation of 3-hydroxy-3,6- dimethylhexahydrobenzofuran-2-one and derivatives thereof | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
| US-20190322635-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
| US-20210230132-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
| US-11434216-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | CYP8B1, DIMT1, DHCR7 | ABCB1 2170/4885MAPT 1654/4885NPC1 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.