Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.54 |
| ▸ | QDPR | P09417 | 3/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8905717 | 0.98 | HTR2C (1.00) | HTR2CSIGMAR1ASIC3QDPRSOS1 | |
| Hydrochloric Acid SCHEMBL1975639 | 0.98 | HTR2C (1.00) | HTR2CSIGMAR1ASIC3QDPRSOS1 | |
| SCHEMBL15806931 | 0.91 | HTR2C (0.83) | HTR2CSIGMAR1ASIC3QDPRSOS1 | |
| SCHEMBL6585457 | 0.87 | HTR2C (0.76) | HTR2CSIGMAR1ASIC3QDPRSOS1 | |
| SCHEMBL15594864 | 0.86 | HTR2C (0.76) | HTR2CSIGMAR1ASIC3SOS1P2RY14 | |
| SCHEMBL10354136 | 0.84 | HTR2C (0.72) | HTR2CSIGMAR1ASIC3PARP10PARP11 | |
| SCHEMBL17232840 | 0.83 | HTR2C (0.71) | HTR2CSIGMAR1QDPRP2RY14 | |
| Hydrochloric Acid SCHEMBL17222909 | 0.82 | HTR2C (0.72) | HTR2CSIGMAR1QDPRP2RY14 | |
| SCHEMBL1472528 | 0.82 | HTR2C (0.69) | HTR2CSIGMAR1QDPRP2RY14 | |
| Hydrochloric Acid SCHEMBL1470460 | 0.80 | HTR2C (0.69) | HTR2CSIGMAR1QDPRP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 250 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005519-A1 | COMBINATIONS OF MEDIUM CHAIN TRIGLYCERIDES AND THERAPEUTIC AGENTS FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE AND OTHER DISEASES RESULTING FROM REDUCED NEURONAL METABOLISM | ACCERA, INC. (US) | 2009-01-08 | — | — | WO | claimed |
| EP-0950052-B1 | METHOD FOR PREPARING A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI SYNTHELABO (FR) | 2004-09-08 | — | — | EP | claimed |
| US-6118006-A | REACTING 4-(3-TRIFLUOROMETHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE WITH2-(2-BROMOETHYL)NAPHTHALENE | SANOFI-SYNTHELABO (FR) | 2000-09-12 | — | — | US | claimed |
| EP-0950052-A1 | METHOD FOR PREPARING A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI-SYNTHELABO (FR) | 1999-10-20 | — | — | EP | claimed |
| WO-1998028273-A1 | METHOD FOR PREPARING A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI (FR) | 1998-07-02 | — | — | WO | claimed |
| US-5462945-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-10-31 | — | — | US | claimed |
| EP-0458697-B1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | SANOFI ELF (FR) | 1994-07-27 | — | — | EP | claimed |
| US-5281606-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1994-01-25 | — | — | US | claimed |
| EP-0498718-A1 | Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydro-pyridine-derivatives as free radical scavengers | ELF SANOFI (FR) | 1992-08-12 | — | — | EP | claimed |
| EP-0458697-A1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | ELF SANOFI (FR) | 1991-11-27 | — | — | EP | claimed |
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | claimed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | claimed |
| EP-0060176-B1 | SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES HAVING ANORECTIC ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-01-02 | — | — | EP | claimed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | claimed |
| EP-0060179-A1 | Pharmaceutical compositions having anorectic activity | SANOFI S.A. (FR) | 1982-09-15 | — | — | EP | claimed |
| EP-0060176-A1 | Substituted trifluoromethylphenyltetrahydropyridines having anorectic activity, their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1982-09-15 | — | — | EP | claimed |
| JP-4312528-A | — | — | None | — | — | JP | disclosed |
| JP-59084865-A | — | — | None | — | — | JP | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |