⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786612 | 1.00 | — | — | |
| SCHEMBL22325343 | 1.00 | — | — | |
| SCHEMBL36205 | 1.00 | — | — | |
| SCHEMBL3987202 | 1.00 | — | — | |
| SCHEMBL22325310 | 1.00 | — | — | |
| SCHEMBL19637966 | 0.89 | — | — | |
| SCHEMBL25282504 | 0.82 | — | — | |
| SCHEMBL835264 | 0.82 | — | — | |
| SCHEMBL80844 | 0.80 | — | — | |
| SCHEMBL10593849 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939509-B2 | Partial and full agonists of A1 adenosine receptors | GILEAD SCIENCES, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20100210579-A1 | PARTIAL AND FULL AGONISTS OF A1 ADENOSINE RECEPTORS | GILEAD PALO ALTO, INC. (US) | 2010-08-19 | — | — | US | disclosed |
| US-7713946-B2 | Partial and full agonists A1 adenosine receptors | CV THERAPEUTICS, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-7655638-B2 | 2-{6-[((1R,2R)-2-hydroxycyclopentyl)amino]purin-9-yl}(4S,5S,2R,3R)-5-[(2-chloro-6-methylphenylthio)methyl]oxolane-3,4-diol; atrial fibrillation, tachycardia and atrial flutter, congestive heart failure, epilepsy, stroke, diabetes, obesity, ischemia, angina, cardiac transplant, and myocardial infarction | GILEAD PALO ALTO, INC. (US) | 2010-02-02 | — | — | US | disclosed |
| US-20090247557-A1 | PARTIAL AND FULL AGONISTS OF A1 ADENOSINE RECEPTORS | GILEAD SCIENCES, INC. | 2009-10-01 | — | — | US | disclosed |
| US-20090203689-A1 | ABCA-1 ELEVATING COMPOUNDS AND METHODS | CV THERAPEUTICS, INC. | 2009-08-13 | — | — | US | disclosed |
| EP-2066645-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB Pharma S.A. (BE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031556-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB PHARMA, S.A. (BE) | 2008-03-20 | — | — | WO | disclosed |
| US-20070185051-A1 | Partial and full agonists of A1 adenosine receptors | GILEAD SCIENCES, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070066560-A1 | Partial and full agonists of A1 adenosine receptors | ELZEIN ELFATIH | 2007-03-22 | — | — | US | disclosed |
| US-7157440-B2 | Partial and full agonists of A1 adenosine receptors | CV THERAPEUTICS, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-6946449-B2 | Partial and full agonists of A1 adenosine receptors | CV THERAPEUTICS, INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050020532-A1 | Partial and full agonists of A1 adenosine receptors | GILEAD PALO ALTO, INC. | 2005-01-27 | — | — | US | disclosed |