Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 7/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
| ▸ | NEK2 | P51955 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616325 | 0.87 | CHEK2 (0.68) | CHEK2CHEK1FYNPIK3CBAXL | |
| SCHEMBL18615580 | 0.75 | PIK3CB (0.55) | CHEK2CHEK1FYNPIK3CBAXL | |
| SCHEMBL23249740 | 0.74 | PDCD1 (0.52) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL18615844 | 0.73 | PIK3CB (0.67) | CHEK2FYNPIK3CBMKNK1TGFBR1 | |
| SCHEMBL18617207 | 0.72 | PIK3CB (0.58) | CHEK2FYNPIK3CBAXLMERTK | |
| SCHEMBL1478747 | 0.71 | CHEK2 (0.61) | CHEK2CHEK1FYNPIK3CBAXL | |
| SCHEMBL18617182 | 0.71 | CHEK2 (0.64) | CHEK2CHEK1FYNPIK3CBMKNK1 | |
| SCHEMBL18615835 | 0.71 | CHEK2 (0.64) | CHEK2FYNPIK3CBMKNK1MKNK2 | |
| SCHEMBL18613347 | 0.71 | FYN (1.00) | CHEK2CHEK1FYNTGFBR1 | |
| SCHEMBL30521707 | 0.71 | FYN (1.00) | CHEK2CHEK1FYNTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |