Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.58 |
| ▸ | BRD2 | P25440 | 2/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | BRD1 | O95696 | 1/20 | 0.50 |
| ▸ | CCL2 | P13500 | 1/20 | 0.50 |
| ▸ | TAF1 | P21675 | 1/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | BPTF | Q12830 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617152 | 0.91 | BRD4 (0.56) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18616079 | 0.90 | BRD4 (0.71) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18584622 | 0.83 | BRD4 (0.77) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18689499 | 0.83 | BRD4 (0.62) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617057 | 0.83 | BRD4 (0.79) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18616184 | 0.82 | BRD4 (0.48) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617830 | 0.82 | BRD4 (0.49) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617248 | 0.81 | BRD4 (0.62) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617903 | 0.80 | BRD4 (0.47) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL18617910 | 0.80 | BRD4 (0.46) | BRD4BRD2BRD3BRDTTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |