SCHEMBL18617699

SCHEMBL18617699

Cc1ncc(CO)c(CNS)c1O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.71
ALDH1A1 P00352 3/20 0.71
HPGD P15428 3/20 0.71
HSD17B10 Q99714 1/20 0.71
LMNA P02545 3/20 0.65
GAA P10253 2/20 0.54
PDXK O00764 3/20 0.54
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CA9 Q16790 3/20 0.50
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
AOX1 Q06278 1/20 0.50
TRIM24 O15164 1/20 0.49
TRIM33 Q9UPN9 1/20 0.49
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
HDAC1 Q13547 2/20 0.46
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7242817 0.88 KDM4E (0.73) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL15586891 0.86 KDM4E (0.71) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL7604712 0.85 KDM4E (0.69) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL6271143 0.85 KDM4E (0.69) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL31010835 0.85 KDM4E (0.69) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL14576441 0.85 KDM4E (0.69) KDM4EALDH1A1HPGDHSD17B10LMNA
Pyridoxine SCHEMBL2322958 0.83 HPGD (1.00) KDM4EALDH1A1HPGDHSD17B10LMNA
Pyridoxine SCHEMBL3506 0.83 HPGD (1.00) KDM4EALDH1A1HPGDHSD17B10LMNA
Pyridoxine SCHEMBL30267871 0.83 HPGD (1.00) KDM4EALDH1A1HPGDHSD17B10LMNA
Pyridoxine SCHEMBL30877002 0.83 HPGD (1.00) KDM4EALDH1A1HPGDHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017037566-A1 COMPOUND, COMPOSITION AND USES THEREOF RAO M SURYA (IN) 2017-03-09 WO disclosed