SCHEMBL18621900

SCHEMBL18621900

CC[C@@H](C)NC(=O)c1cc(N2CCC(c3n[nH]c4ncccc34)CC2)nc(OCC2CC2)n1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 20/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17837698 0.94 AXL (0.66) AXL
SCHEMBL18621875 0.94 AXL (0.61) AXL
SCHEMBL17861751 0.91 AXL (0.79) AXL
SCHEMBL18621874 0.91 AXL (0.71) AXL
SCHEMBL18622003 0.90 AXL (0.69) AXL
SCHEMBL18622000 0.90 AXL (0.69) AXL
SCHEMBL17857719 0.88 AXL (0.69) AXL
SCHEMBL17837888 0.87 AXL (0.63) AXL
SCHEMBL17837853 0.87 AXL (0.63) AXL
SCHEMBL17837602 0.85 AXL (0.79) AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9593097-B2 Axl inhibitors PFIZER INC. (US) 2017-03-14 — — US disclosed
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