Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18629694 | 0.88 | GRIN2B (0.79) | GRIN2BGRIN1ACHE | |
| SCHEMBL16600800 | 0.85 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL18629695 | 0.82 | GRIN2B (0.69) | GRIN2BGRIN1 | |
| SCHEMBL20858749 | 0.81 | GRIN2B (0.81) | GRIN2BGRIN1 | |
| SCHEMBL16608160 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL16601041 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL16601092 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL30076111 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL16608237 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL16601043 | 0.77 | GRIN2B (0.66) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | LUC THERAPEUTICS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | LUC THERAPEUTICS, INC. | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885GRIN1 6/4885ACHE 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.