SCHEMBL18625328

SCHEMBL18625328

C[C@@H](NC(=O)c1nc(OCOC#N)nc(N2CCC(COc3cncnc3N)CC2)n1)C1CC1

nearest known ligand 0.79

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AXL P30530 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17837377 0.88 AXL (1.00) AXL
SCHEMBL18625609 0.88 AXL (1.00) AXL
SCHEMBL17837725 0.88 AXL (1.00) AXL
SCHEMBL18625409 0.88 AXL (1.00) AXL
SCHEMBL17837826 0.88 AXL (1.00) AXL
SCHEMBL18625408 0.87 AXL (0.82) AXL
SCHEMBL18625585 0.87 AXL (0.82) AXL
SCHEMBL17857775 0.86 AXL (0.79) AXL
SCHEMBL17837803 0.79 AXL (1.00) AXL
SCHEMBL18621947 0.78 AXL (0.82) AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9593097-B2 Axl inhibitors PFIZER INC. (US) 2017-03-14 US disclosed