SCHEMBL18625403

SCHEMBL18625403

CC1C=C(NC(=O)c2nc(OC[C@H]3C[C@H]3C#N)nc(N3CCC(COc4cc(-c5cn(C)cn5)cnc4N)CC3)n2)C1

nearest known ligand 0.80

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AXL P30530 20/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18625401 0.89 AXL (0.81) AXL
SCHEMBL17837609 0.89 AXL (1.00) AXL
SCHEMBL17863907 0.89 AXL (1.00) AXL
SCHEMBL18625372 0.89 AXL (1.00) AXL
SCHEMBL17837913 0.89 AXL (1.00) AXL
SCHEMBL17837467 0.88 AXL (0.84) AXL
SCHEMBL17837409 0.88 AXL (0.83) AXL
SCHEMBL17837958 0.87 AXL (1.00) AXL
SCHEMBL17837637 0.83 AXL (0.75) AXL
SCHEMBL17844554 0.83 AXL (0.75) AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9593097-B2 Axl inhibitors PFIZER INC. (US) 2017-03-14 US disclosed