SCHEMBL18625666

SCHEMBL18625666

C[C@H](NC(=O)c1nc(OC[C@H]2CC2C#N)nc(N2CCC(c3n[nH]c4ncccc34)CC2)n1)C1CC1

nearest known ligand 0.79

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17838011 1.00 AXL (0.79) AXL
SCHEMBL18625304 1.00 AXL (0.79) AXL
SCHEMBL17837596 1.00 AXL (0.79) AXL
SCHEMBL18625303 0.91 AXL (0.65) AXL
SCHEMBL18625665 0.91 AXL (0.65) AXL
SCHEMBL17837974 0.91 AXL (0.80) AXL
SCHEMBL18625695 0.91 AXL (0.80) AXL
SCHEMBL21240821 0.91 AXL (0.80) AXL
SCHEMBL18625660 0.88 AXL (0.79) AXL
SCHEMBL17837807 0.88 AXL (0.79) AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9593097-B2 Axl inhibitors PFIZER INC. (US) 2017-03-14 — — US disclosed
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