Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.80 |
| ▸ | FAP | Q12884 | 3/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.80 |
| ▸ | POU2F2 | P09086 | 1/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.80 |
| ▸ | POU2F1 | P14859 | 1/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.80 |
| ▸ | HRH2 | P25021 | 1/20 | 0.80 |
| ▸ | MC4R | P32245 | 1/20 | 0.80 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.80 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.80 |
| ▸ | GHSR | Q92847 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19154442 | 1.00 | DPP4 (0.80) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL20895845 | 1.00 | DPP4 (0.80) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL16392282 | 0.95 | DPP4 (0.82) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL2949897 | 0.93 | DPP4 (0.83) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL1771774 | 0.92 | DPP4 (0.84) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL1771776 | 0.92 | DPP4 (0.84) | DPP4FAPCHRM1POU2F2ADORA3 | |
| SCHEMBL20895832 | 0.90 | DPP4 (0.65) | DPP4FAPCHRM1POU2F2ADORA3 | |
| Linagliptin SCHEMBL160188 | 0.89 | DPP4 (1.00) | DPP4FAPCHRM1POU2F2ADORA3 | |
| Linagliptin SCHEMBL28983978 | 0.89 | DPP4 (1.00) | DPP4FAPCHRM1POU2F2ADORA3 | |
| Linagliptin SCHEMBL29359185 | 0.89 | DPP4 (1.00) | DPP4FAPCHRM1POU2F2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190434-B1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2019-04-17 | — | — | EP | claimed |
| US-9593119-B2 | Process for the preparation of dipeptidylpeptidase inhibitors | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2017-03-14 | — | — | US | disclosed |