Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 5/20 | 0.39 |
| ▸ | CCND1 | P24385 | 5/20 | 0.39 |
| ▸ | CCND3 | P30281 | 5/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18627930 | 0.95 | SYK (0.43) | SYKSMG1MTORCCNT1CDK9 | |
| SCHEMBL18627912 | 0.93 | SMG1 (0.44) | SYKSMG1MTORCCNT1CDK9 | |
| SCHEMBL18627927 | 0.90 | SYK (0.43) | SYKSMG1MTORKDM4EMEN1 | |
| SCHEMBL18627951 | 0.88 | SYK (0.47) | SYKSMG1CCNT1CDK9CDK2 | |
| SCHEMBL18627908 | 0.88 | SYK (0.47) | SYKSMG1CCNT1CDK9CDK2 | |
| SCHEMBL18627910 | 0.88 | SYK (0.47) | SYKSMG1CCNT1CDK9CDK2 | |
| SCHEMBL18627918 | 0.87 | SYK (0.45) | SYKSMG1CCNT1CDK9CDK2 | |
| SCHEMBL18627896 | 0.85 | SYK (0.43) | SYKSMG1CCNT1CDK9CDK2 | |
| SCHEMBL18627919 | 0.85 | SYK (0.43) | SYKSMG1MTORCCNT1CDK9 | |
| SCHEMBL18627955 | 0.85 | SYK (0.45) | SYKSMG1MTORCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350176-B1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2021-04-28 | — | — | EP | claimed |
| US-10392373-B2 | Oxazole derivatives that inhibit Syk | AB SCIENCE (FR) | 2019-08-27 | — | — | US | claimed |
| US-20190055230-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2019-02-21 | — | — | US | claimed |
| EP-3144307-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB Science (FR) | 2017-03-22 | — | — | EP | claimed |
| EP-3350176-B1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2021-04-28 | — | — | EP | disclosed |
| US-10392373-B2 | Oxazole derivatives that inhibit Syk | AB SCIENCE (FR) | 2019-08-27 | — | — | US | disclosed |
| US-10392373-B2 | Oxazole derivatives that inhibit Syk | AB SCIENCE (FR) | 2019-08-27 | — | — | US | disclosed |
| US-20190055230-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2019-02-21 | — | — | US | disclosed |
| US-20190055230-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2019-02-21 | — | — | US | disclosed |
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | disclosed |
| EP-3144307-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB Science (FR) | 2017-03-22 | — | — | EP | disclosed |
| EP-3144307-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB Science (FR) | 2017-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190055230-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | SYK, BTK, LCK | SYK 1/4885SMG1 968/4885MTOR 424/4885 |
| US-10392373-B2 | Oxazole derivatives that inhibit Syk | SYK, BTK, LCK | SYK 1/4885SMG1 950/4885MTOR 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.