Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 15/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18628376 | 1.00 | SMO (0.64) | SMOHRH3EPHX2SSTR4 | |
| SCHEMBL18628475 | 1.00 | SMO (0.64) | SMOHRH3EPHX2SSTR4 | |
| SCHEMBL18628411 | 0.92 | SMO (0.61) | SMOHRH3EPHX2 | |
| SCHEMBL18628473 | 0.90 | SMO (0.66) | SMO | |
| SCHEMBL18628362 | 0.89 | SMO (0.65) | SMO | |
| SCHEMBL2160482 | 0.89 | SMO (0.65) | SMO | |
| SCHEMBL2160487 | 0.89 | SMO (0.65) | SMO | |
| SCHEMBL18628357 | 0.87 | SMO (0.60) | SMOHRH3EPHX2 | |
| SCHEMBL2160854 | 0.87 | SMO (0.60) | SMOHRH3EPHX2 | |
| SCHEMBL18628365 | 0.87 | SMO (0.60) | SMOHRH3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334683-B1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | MSD ITALIA SRL (IT) | 2017-03-22 | — | — | EP | disclosed |