Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.42 |
| ▸ | CDK9 | P50750 | 5/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10304511 | 0.88 | CCNT1 (0.48) | CCNT1CDK9 | |
| SCHEMBL10008352 | 0.87 | CCNT1 (0.40) | CCNT1 | |
| SCHEMBL10303502 | 0.85 | CCNT1 (0.42) | CCNT1CDK9 | |
| SCHEMBL15723264 | 0.85 | CCNT1 (0.42) | CCNT1CDK9 | |
| SCHEMBL10007567 | 0.85 | CCNT1 (0.39) | CCNT1CDK9 | |
| SCHEMBL10007848 | 0.85 | JAK3 (0.40) | CCNT1 | |
| SCHEMBL10007573 | 0.85 | CCNT1 (0.39) | CCNT1CDK9 | |
| SCHEMBL10007851 | 0.85 | JAK3 (0.40) | CCNT1 | |
| SCHEMBL10007872 | 0.84 | GAA (0.42) | CCNT1CDK9 | |
| SCHEMBL10007867 | 0.84 | GAA (0.42) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3427738-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3427738-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-3141252-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-3141252-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2017-03-15 | — | — | EP | disclosed |