Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 19/20 | 0.64 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666839 | 0.90 | TRPV1 (0.57) | TRPV1MAPK3MAOAKCNH2SCN9A | |
| SCHEMBL1865975 | 0.89 | TRPV1 (0.67) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1858546 | 0.89 | TRPV1 (0.62) | TRPV1MAPK3SCN9A | |
| SCHEMBL1863793 | 0.88 | TRPV1 (0.64) | TRPV1MAPK3MAOAKCNH2SCN9A | |
| SCHEMBL1865075 | 0.88 | TRPV1 (0.70) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1863481 | 0.87 | TRPV1 (0.70) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1860025 | 0.87 | TRPV1 (0.69) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1864308 | 0.87 | TRPV1 (0.62) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1866310 | 0.85 | TRPV1 (0.66) | TRPV1MAPK3MAOAKCNH2 | |
| SCHEMBL1862099 | 0.84 | TRPV1 (0.63) | TRPV1MAPK3MAOAKCNH2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |