Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 9/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12079572 | 0.99 | GCKR (0.48) | GCKRSLC6A2SLC6A4SLC6A3NR1I2 | |
| SCHEMBL12089485 | 0.85 | SLC6A2 (0.46) | GCKRSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL18202 | 0.83 | GCKR (0.47) | GCKRNR1I2RORCNR1H2NR1H3 | |
| SCHEMBL19294 | 0.83 | GCKR (0.47) | GCKRNR1I2RORCNR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL12078148 | 0.82 | GCKR (0.46) | GCKRNR1I2RORCNR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL16350 | 0.82 | GCKR (0.46) | GCKRNR1I2RORCNR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL16351 | 0.82 | GCKR (0.46) | GCKRNR1I2RORCNR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL12078152 | 0.82 | GCKR (0.46) | GCKRNR1I2RORCNR1H2NR1H3 | |
| SCHEMBL5631142 | 0.79 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5632263 | 0.79 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |